Platform  Description  Value added  Future
 opportunities
  Enteric
  coated
  tablets		 Delayed release tablets
  • Ensure bioavailability

  • Protection of acid-sentsitive drugs
 Drugs unstable in gastric fluid, absorption in duodenum and jejunum
  Matrix
  pellets		 Granulation, extrusion
spheronisation
(optionally coating)
- Substained release
pellets
  • Adjustment of dissolution profile

  • Obtaining bioequivalence

  • Fewer adverse reactions
 Substained release preparations, fewer dosings, fewer adverse reactions
  Sustained
  release
  pellets		 Extrusion, spheronisation, coating
- sustained release pellets
  • Adjustment of dissolution profile

  • Obtaining bioequivalence

  • Fewer adverse reactions
 Substained release preparations, fewer dosings, fewer adverse reactions
  Active coated
  pellets Melt
  coat		 Non-pareil, wax and API granulated
- modified release can be applied by coating
  • Possible stabilization of moisture sensitive APIs
 Possible stabilization of moisture sensitive APIs
  Active coated
  pellets Spray
  coating		 Spray coating of solution/suspension of API on non-pareils
- modified release applied by coating
  • Possible increased solubility rate of API which ensures that coating is release controlling
 Substained release preparations, fewer dosings, fewer adverse reactions
TECHNOLOGY PLATFORMS 1/3